Histone deacetylases govern heterochromatin in every phase.
نویسنده
چکیده
Deacetylation of histone tails has been shown to play a role during heterochromatin formation, but the precise mechanism of action has not been understood. Complementary results presented in two recent articles in The EMBO Journal (Alper et al, 2013; Buscaino et al, 2013) together reveal how histone deacetylases (HDACs) affect the various phases of heterochromatin formation: establishment, maintenance and spreading. Heterochromatin, condensed chromatin that is transcriptionally inactive, plays important roles in epigenetic
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عنوان ژورنال:
- The EMBO journal
دوره 32 17 شماره
صفحات -
تاریخ انتشار 2013